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Biblioteca(s): |
Embrapa Caprinos e Ovinos. |
Data corrente: |
08/05/2009 |
Data da última atualização: |
08/05/2009 |
Autoria: |
MONTE, A. B.; GOMES, S. M. C.; CAMPOS, T. C. |
Título: |
Análise econômica de um sistema de engorda de ovinos no nordeste do Brasil. |
Ano de publicação: |
2000 |
Fonte/Imprenta: |
In:CONGRESSO MUNDIAL DE SOCIOLOGIA RURAL, 10.; CONGRESSO BRASILEIRO DE ECONOMIA E SOCIOLOGIA RURAL, 38., 2000, Rio de Janeiro. Anais... Rio de Janeiro: SOBER, 2000. 14 f. 1 CD-ROM. |
Idioma: |
Português |
Palavras-Chave: |
Brasil; Nordeste; Ovino de corte. |
Thesagro: |
Análise Econômica; Engorda. |
Categoria do assunto: |
-- |
Marc: |
LEADER 00664naa a2200193 a 4500 001 1532798 005 2009-05-08 008 2000 bl uuuu u00u1 u #d 100 1 $aMONTE, A. B. 245 $aAnálise econômica de um sistema de engorda de ovinos no nordeste do Brasil. 260 $c2000 650 $aAnálise Econômica 650 $aEngorda 653 $aBrasil 653 $aNordeste 653 $aOvino de corte 700 1 $aGOMES, S. M. C. 700 1 $aCAMPOS, T. C. 773 $tIn:CONGRESSO MUNDIAL DE SOCIOLOGIA RURAL, 10.; CONGRESSO BRASILEIRO DE ECONOMIA E SOCIOLOGIA RURAL, 38., 2000, Rio de Janeiro. Anais... Rio de Janeiro: SOBER, 2000. 14 f. 1 CD-ROM.
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Embrapa Caprinos e Ovinos (CNPC) |
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Registro Completo
Biblioteca(s): |
Embrapa Florestas. |
Data corrente: |
23/04/2021 |
Data da última atualização: |
23/04/2021 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Circulação/Nível: |
A - 1 |
Autoria: |
THÁ, E. L.; MATOS, M.; AVELINO, F.; LOMONACO, D.; RODRIGUES-SOUZA, I.; GAGOSIAN, V. S. C.; CESTARI, M. M.; MAGALHAES, W. L. E.; LEME, D. M. |
Afiliação: |
EMANOELA LUNDGREN THÁ, Pós-graduanda da UFPR; MAILSON MATOS, Pós-graduando da UFPR; FRANCISCO AVELINO, Instituto Federal de Educação, Ciência e Tecnologia do Ceará; DIEGO LOMONACO, Universidade Federal do Ceará; ISISDORIS RODRIGUES-SOUZA, Pós-graduanda da UFPR; VIVIANA STEPHANIE COSTA GAGOSIAN, Pós-graduanda da UFPR; MARTA MARGARETE CESTARI, Pós-graduanda da UFPR; WASHINGTON LUIZ ESTEVES MAGALHAES, CNPF; DANIELA MORAIS LEME, UFPR. |
Título: |
Safety aspects of kraft lignin fractions: discussions on the in chemico antioxidant activity and the induction of oxidative stress on a cell-based in vitro model. |
Ano de publicação: |
2021 |
Fonte/Imprenta: |
International Journal of Biological Macromolecules, v. 182, p. 977-986, Apr. 2021. |
DOI: |
https://doi.org/10.1016/j.ijbiomac.2021.04.103 |
Idioma: |
Inglês |
Conteúdo: |
Lignin is a complex phenolic biopolymer present in plant cell walls and a by-product of the cellulose pulping industry. Lignin has functional properties, such as antioxidant activity, that make it a potential natural active ingredient for health-care products. However, not all safety aspects of lignin fractions have been adequately investigated. Herein, we evaluated the antioxidant and genotoxic potential of two hardwood kraft lignins (F3 and F5). The chemical characterization of F3 and F5 demonstrated their thermal stability and the presence of different phenolic units, while the DPPH assay confirmed the antioxidant activity of these lignin fractions. Despite being antioxidants in the DPPH assay, F3 and F5 were capable of generating intracellular reactive oxygen species (ROS) and subsequently causing oxidative DNA damage (Comet assay) in HepG2 cells. The biological relevance of the DPPH assay might be uncertain in some cases; therefore, we suggest combining in chemico tests with biological system-based tests to determine efficacy and safety levels of lignins and define appropriate applications of lignins for consumer products. Moreover, kraft lignins obtained by acid precipitation may pose risks to human health; however, as genotoxicity is not the sole endpoint of toxicity required in hazard assessments, additional toxicological evaluations are needed. |
Palavras-Chave: |
DNA oxidation; DPPH assay; Hardwood lignin; Intracellular ROS; Lignina de foliosa; Oxidação do DNA. |
Categoria do assunto: |
X Pesquisa, Tecnologia e Engenharia |
Marc: |
LEADER 02373naa a2200301 a 4500 001 2131487 005 2021-04-23 008 2021 bl uuuu u00u1 u #d 024 7 $ahttps://doi.org/10.1016/j.ijbiomac.2021.04.103$2DOI 100 1 $aTHÁ, E. L. 245 $aSafety aspects of kraft lignin fractions$bdiscussions on the in chemico antioxidant activity and the induction of oxidative stress on a cell-based in vitro model.$h[electronic resource] 260 $c2021 520 $aLignin is a complex phenolic biopolymer present in plant cell walls and a by-product of the cellulose pulping industry. Lignin has functional properties, such as antioxidant activity, that make it a potential natural active ingredient for health-care products. However, not all safety aspects of lignin fractions have been adequately investigated. Herein, we evaluated the antioxidant and genotoxic potential of two hardwood kraft lignins (F3 and F5). The chemical characterization of F3 and F5 demonstrated their thermal stability and the presence of different phenolic units, while the DPPH assay confirmed the antioxidant activity of these lignin fractions. Despite being antioxidants in the DPPH assay, F3 and F5 were capable of generating intracellular reactive oxygen species (ROS) and subsequently causing oxidative DNA damage (Comet assay) in HepG2 cells. The biological relevance of the DPPH assay might be uncertain in some cases; therefore, we suggest combining in chemico tests with biological system-based tests to determine efficacy and safety levels of lignins and define appropriate applications of lignins for consumer products. Moreover, kraft lignins obtained by acid precipitation may pose risks to human health; however, as genotoxicity is not the sole endpoint of toxicity required in hazard assessments, additional toxicological evaluations are needed. 653 $aDNA oxidation 653 $aDPPH assay 653 $aHardwood lignin 653 $aIntracellular ROS 653 $aLignina de foliosa 653 $aOxidação do DNA 700 1 $aMATOS, M. 700 1 $aAVELINO, F. 700 1 $aLOMONACO, D. 700 1 $aRODRIGUES-SOUZA, I. 700 1 $aGAGOSIAN, V. S. C. 700 1 $aCESTARI, M. M. 700 1 $aMAGALHAES, W. L. E. 700 1 $aLEME, D. M. 773 $tInternational Journal of Biological Macromolecules$gv. 182, p. 977-986, Apr. 2021.
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